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WebJun 8, 2024 · Sleep aids available without a prescription can be effective for an occasional sleepless night. There are a few caveats, however. Most sleep aids available without a prescription contain antihistamines. Tolerance to the sedative effects of antihistamines can develop quickly. The longer you take them, the less likely they are to make you sleepy. WebOpioids work by blocking your brain’s sensation of pain. They can also affect the pleasure center of your brain, causing a sense of euphoria. When taken as directed, opioids can … WebDec 19, 2015 · Narcotic tolerance can lead to dependence and addiction. According to the National Institute on Drug Abuse, “Tolerance occurs when the person no longer … can i use swai for fish tacos