WebOct 1, 2024 · Quantifying clonality, diversity and convergence of TCR repertoires. Aside from the diversity in antigenic specificity of T-cell repertoires (i.e. the epitome), … WebOct 1, 2024 · Using high-sensitivity, error-corrected targeted sequencing methods, clones with VAFs of <0.1% can be found, and virtually all individuals will have evidence of this degree of clonal expansion by age 50 years. 1 However, the clinical significance of very small (<1% VAF) clones is unclear.

RNA sequencing identifies clonal structure of T-cell repertoires …

WebJun 22, 2024 · We discover transcriptional differences between memory cells in lungs and lymphoid organs and organ-restricted clonal expansion. Remarkably, we find significant clonal overlap between GC-derived memory and plasma cells. WebFeb 24, 2024 · The underlying processes associated with clonal expansion are best studied by detecting somatic mutations or other acquired alterations, such as copy number variations and DNA methylation,... chihuahua pekingese mix lifespan

T-cell repertoire analysis and metrics of diversity and clonality

WebApr 15, 2015 · To explore the clonal status of mutations in established cancer genes, we first identified all nonsilent mutations that occurred in known cancer driver genes based on the recent pan-cancer analysis by Lawrence et al. ( 1) combined with the manually curated COSMIC gene census ( 23) (table S1). WebFeb 3, 2024 · Ecological adaptation plays an important role in the process of plant expansion, and genetics and epigenetics are important in the process of plant adaptation. In this study, genetic and epigenetic analyses and soil properties were performed on D. angustifolia of 17 populations, which were selected in the tundra zone on the western … WebMay 20, 2024 · Here we summarize our current understanding of the clonal expansion of mitochondrial DNA mutations in different tissues and highlight key unanswered questions. We then discuss the various existing biological … chihuahua paw print clip art