WebJan 6, 2024 · Klotho, a remarkable protein with powerful anti-aging properties has recently been investigated for its role in musculoskeletal health and physical function. Klotho is involved in several key processes that regulate skeletal muscle function, such as muscle regeneration, mitochondrial biogenesis, endothelial function, oxidative stress, and ... WebAug 29, 2024 · Klotho is a well-established longevity hormone. Its most prominent function is the regulation of phosphate homeostasis. However, klotho possesses multiple pleiotropic activities, including ...
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WebDec 18, 2024 · In the kidney, Klotho, serving as a co-receptor for FGF23 (fibroblast growth factor-23), promotes urinary excretion of phosphorus and maintains phosphate homeostasis. 19, 20 In mice, Klotho deficiency exaggerates isoproterenol-induced pathological cardiac hypertrophy and remodeling, while Klotho overexpression … WebJul 4, 2024 · Klotho is a well-known anti-aging hormone, which serves as a suppressor of aging through a variety of mechanisms. Aging of skeletal muscle is concomitant with a decrease in muscle stem cell function resulting in impaired regeneration. Here we investigate the functional role of the anti-aging hormone Klotho for muscle stem cell … 58校招内推
What is Klotho? The Klotho Protein - YourDNA
WebMar 6, 2024 · Klotho functions as a co-receptor for fibroblast growth factor 23 (FGF23) signaling, whereas its shed extracellular domain, soluble Klotho (sKlotho), carrying … WebKlotho is an anti-aging protein with pleiotropic actions that exerts organ protection. Several lines of evidence support the notion that Klotho functions as a human aging-suppression … WebKlotho is an anti-aging factor mainly produced by renal tubular epithelial cells (TEC) with pleiotropic functions. Klotho is down-regulated in acute kidney injury in native kidney; … 58校招内推码