Klotho heart
WebMar 22, 2024 · Heart disease is the leading cause of death worldwide. The major cause of heart failure is the death of the myocardium caused by myocardial infarction, detrimental cardiac remodeling, and cardiac fibrosis occurring after the injury. This study aimed at discovering the role of the anti-aging protein α-klotho (KL), which is the co-receptor of … WebJun 20, 2024 · The α-Klotho predominantly exists in two forms as follows: a single-pass transmembrane protein and a soluble protein that circulates in the blood, urine, and …
Klotho heart
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WebJan 1, 2024 · The soluble Klotho might protect the diseased heart and ameliorates symptoms among patients with heart failure; Jiasheng Cai isresponsible for data curation, … WebApr 12, 2024 · Tags: F-Klb, FGF21, Heart Disease, Klotho. Previous Post. About the author. Josh Conway Josh is a professional editor and is responsible for editing our articles before they become available to the public as well as moderating our Discord server. He is also a programmer, long-time supporter of anti-aging medicine, and avid player of the strange ...
WebFeb 19, 2024 · Conclusions: Klotho deficiency causes cardiac aging via impairing the Nrf2-GR pathway. Supplement of exogenous secreted Klotho represents a promising … WebJan 1, 2012 · How appropriate that Klotho, the Greek goddess of life, is involved in vascular disease. Klotho is one of the Greek Moirai, the goddesses of fate who controlled the ultimate destiny of man: death. ... a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology ...
WebApr 18, 2024 · The associations among Klotho (exposure), congestive heart failure (CHF; outcome), and renal function markers [estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), uric acid (UA), and urine albumin-to-creatinine ratio (UACR); mediators] were investigated using mediation analysis. WebApr 15, 2024 · Klotho, a protein that exists in two forms, membrane-bound Klotho and soluble Klotho, and acts as co-receptor for fibroblast growth factor 23 (FGF23), has been …
WebMay 30, 2024 · Klotho is an antiaging protein which exerts known cardioprotection. In kidney, trans-membrane Klotho acts as essential co-receptor of fibroblast growth factor …
WebMar 22, 2024 · Heart disease is the leading cause of death worldwide. The major cause of heart failure is the death of the myocardium caused by myocardial infarction, detrimental … insurance for living abroadWebKlotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo. Cardiac inflammation and oxidative … jobs in brighton coloradoWebFeb 18, 2024 · Furthermore, these elegant studies also reveal that secreted Klotho might be a viable therapeutic for the treatment of cardiac aging as well as other cardiovascular diseases, such as heart failure, that are characterized by increased myocardial oxidative stress and cell death.10 However, several challenges would need to be overcome to … jobs in brisbane cityWebKlotho is an antagonist of the Wnt signaling pathway, and chronic Wnt stimulation can lead to stem cell depletion and aging. Klotho inhibition of Wnt signaling can inhibit cancer. The … jobs in brinkworthWebNov 1, 2009 · Emergence of osteoblast-like cells in the calcified aorta from klotho −/− mouse in vivo. A: klotho expression in human coronary artery endothelial cells (HCAEC) and smooth muscle cells (HCASMC) was analyzed by RT-PCR. B: the aorta was extracted from a 3-wk-old klotho −/− mouse, and the serial sections were subjected to histochemical ... insurance for long term travelWebDec 13, 2016 · We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10 −12). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and … insurance for long term care costsWebKlotho is mainly produced in the kidneys. 6 Its deficiency is associated with the progression of chronic kidney disease and heart disease. Low levels of Klotho in patients with chronic kidney disease can also promote vessel calcification and salt-dependent hypertension. 13 , 14 Animal studies indicate a nephroprotective role of Klotho probably ... insurance for losing job