WebMar 7, 2024 · The peroxynitrite formed can attack a wide range of biomolecules via direct oxidative reactions or indirect radical-mediated mechanisms thus triggering cellular … WebJan 20, 2015 · Peroxynitrite is formed in biological systems when nitric oxide and superoxide rapidly interact at near equimolar ratio. Peroxynitrite, though not a free radical …
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WebOct 1, 2024 · During GE, many cytolytic pathways are activated with or from the overload in calcium, including the intrinsic apoptosis pathway, mitochondrial permeability transition, lysosomal cell death, necrotic type cell deaths (oncosis, parthanatos, phagoptosis), ferroptosis, and reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced … WebThe lysosome, which acts as the cellular recycling centre, is filled with numerous hydrolases that can degrade most cellular macromolecules. The abnormalities of the lysosome are … dictionary\u0027s 8e
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WebJul 29, 2024 · Peroxynitrite (ONOO − ), as an important reactive oxygen species (ROS), holds great potential to react with a variety of biologically active substances, leading to the … WebAug 10, 2024 · Background. The lysosomal storage diseases are a group of inborn errors of metabolism with multisystemic impairment and chronic progression, induced by the deficiency of lysosomal acid hydrolases involved in the breakdown of various macromolecules [].Normally these substances are degraded in the lysosomes into small … WebApr 12, 2024 · Mutations in glucocerebrosidase cause the lysosomal storage disorder Gaucher’s disease and are the most common risk factor for Parkinson’s disease. Therapies to restore the enzyme’s function ... dictionary\u0027s 8i