Phospho-4ebp1

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August undefined, 2024

Web当你希望让更多商家联系你时，可以勾选后发送询价，平台会将你的询价消息推荐给更多商家。 WebJun 6, 1999 · National Center for Biotechnology Information

DRAM1 regulates autophagy and cell proliferation via inhibition of …

WebApr 1, 2024 · We also engineered a mutant 4E-BP1 that cannot be phosphorylated by mTOR resembling de-phospho-Thr46-4E-BP1, and generated HNSCC cells expressing this mutant in a tetracycline-inducible fashion. Expression of 4E-BP1 M was sufficient to disrupt the function of the translation–initiation complex, and resulted in tumor regression in HNSCC ... WebThe aim of this study was to evaluate the role of phosphorylated 4EBP1 (p4EBP1) in primary renal cell carcinoma (RCC) as a biomarker in metastatic RCC (mRCC) and non-mRCC … chipping norton flights

Phospho-4EBP1 (Thr37, Thr46) Polyclonal Antibody

WebListed below are anti-4EBP1 antibodies from multiple suppliers. 4EBP1 is a reported alias name for the human gene EIF4EBP1, or 'eukaryotic translation initiation factor 4E binding … WebJan 9, 2012 · MPTECs were tranduced either with empty vector or NL4-3 and then incubated in media for 72 hours. Subsequently, proteins were extracted from vector/MPTECs and HIV/MPTECs, Western blots were prepared and probed for phospho-70S6K, phospho-eIF4B, and phospho-4EBP1. Immunoblots were stripped and reprobed for actin (n = 4). A. Web骨骼肌细胞I带内只有 [外源性IGF-I对大鼠运动骨骼肌mTOR及下游信号的影响].docx chipping norton fau

Phospho-4EBP1 (Thr37, Thr46) Recombinant Monoclonal …

WebPhospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to rapamycin treatment in vitro p-mTOR expression was associated with nuclear p-4EBP1 expression (P = 0.02), and was more frequent in tumors extending ouside the uterine corpus (P = 0.011). WebPhospho-4E-BP1 (Ser65) Antibody detects endogenous levels of 4E-BP1 when phosphorylated at serine 65. This antibody has been shown to also recognize 4E-BP1 … chipping norton events hireWebImmunoprecipitation of Phospho-4E-BP1 (Ser65) from MCF-7 cell extracts. Cells were starved for 24 hours in serum-free medium and underwent a 1 hour amino acid deprivation. Amino acids were replenished for 1 hour. Cells were then treated with 100 nM insulin for 30 minutes. Lane 1 is 10% input, lane 2 is Normal Rabbit IgG #2729, and lane 3 is ... chipping norton flooding

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Phospho-4ebp1

WebJan 2, 2024 · Here we demonstrate that rapamycin-insensitive mTORC1 signaling via 4E-BP1 is a critical pathway for TGF-β 1 stimulated collagen synthesis in human lung fibroblasts, whereas canonical PI3K/Akt... WebPhospho-4EBP1 (Thr37, Thr46) Antibody (MA5-36936) in Flow Flow cytometry of Phospho-EIF4EBP1 (Thr37, Thr46) using Jurkat cells. Samples were incubated in monoclonal Phospho-EIF4EBP1 (Thr37, Thr46) antibody ( Product # MA5-36936 ).

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WebSep 11, 2024 · Glioblastoma is the most common malignant primary brain tumor, and it is one of the causes of cancer fatality in both adult and pediatric populations. Patients with glioblastoma require chemotherapy after surgical resection and radiotherapy. Therefore, chemotherapy constitutes a viable approach for the eradication of glioblastoma cells. In … WebMay 19, 2015 · Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors PLoS One doi: 10.1371/journal.pone.0127123. eCollection 2015. Authors

Web实验用到的供体是Thr46（铽标记的anti-phospho-4EBP1），受体是绿色荧光标记的4EBP1，是mTOR下游信号通路的蛋白，有活性的mTOR能磷酸化4EBP1，使之与供体结合。如果mTOR活性受到抑制，供体受体距离不能达到荧光能量转移的要求，则在515nm处与485nm处的信号比值增大。 WebPrimary Antibodies (9010) Secondary Antibodies (76) Antibody Conjugates (1994) Activators & Inhibitors (224) Buffers & Dyes (108) Cellular Assay Kits (118) ChIP Kits & Reagents (156) CUT&RUN Kits & Reagents (15) Cytokines & Growth Factors (215) ELISA Kits (513) Experimental Controls (248) Flow Cytometry Kits & Reagents (9) Proteomic Analysis …

WebPhospho-4EBP1 (Thr46) Antibody (44-1170G) in ICC/IF Immunofluorescence analysis of 4EBP1 (pT46) was done on 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature.

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WebMar 22, 2024 · DRAM1 also dramatically downregulated the phosphorylation of both rpS6 at Ser 240/244 (Fig. 2 a and c) and 4EBP1 (Fig. 2 a and d), suggesting that the activity of p70S6K was decreased, though the phosphorylation of mTOR itself had no change (Fig. 2 a). chipping norton extra time clubWebEukaryotic translation initiation factor 4E‑binding protein 1 (4EBP1) is phosphorylated and activated by mammalian target of rapamycin complex 1, which serves as a regulator of cell growth, cell survival, metastasis and angiogenesis in many types of cancer. chipping norton floristWebKeyTec®TR-FRET Phospho-STAT4 (Y693) Kit : KeyTec®TR-FRET Phospho-STAT5 (Y694/Y699) Kit : KeyTec®TR-FRET Total STAT5 Kit : KeyTec®TR-FRET Phospho-STAT6 (Y641) Kit : KeyTec®TR-FRET Total STAT6 Kit : KeyTec®TR-FRET Phospho-4EBP1 (T37/T46) Kit : KeyTec®TR-FRET Total 4EBP1 Kit : KeyTec®TR-FRET Phospho-BTK … chipping norton food bankWebThe ER is the main organelle for calcium (Ca 2+) storage in cells.Its physiological function is closely related to Ca 2+ homeostasis (Wong et al., 1993).To investigate the effect of As 3+ /Se 4+ combination on ER function, this study pretreated cells with ERS inducer thapsigargin (TG) and ERS inhibitor 2-aminoethoxydiphenyl borate (2-APB), followed by Fluo-3-AM and … grape nuts with datesWebApr 14, 2024 · Neuropathic pain caused by trigeminal nerve injury is a typical refractory orofacial chronic pain accompanied by the development of hyperalgesia and allodynia. We previously demonstrated that the mammalian target of rapamycin (mTOR) inhibitor rapamycin suppressed orofacial formalin injection-induced nociception; however, the … grape nuts yearWebMay 19, 2015 · Thus, phospho-4EBP1 (Thr37/46) is not suited to indicate activation of sensitive signaling or to monitor effective target inhibition for 1 st generation mTORC1 inhibitor therapy. In line with these findings, in vitro experiments using myotubes showed the absence of an effect on phosphorylation of 4EBP1 after rapamycin treatment . grape off株式会社WebGeneral notes. This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity and specificity. - Long-term security of supply. - Animal-free production. For more information see here. chipping norton folk club