WebThe mTORC1 (mechanistic target of rapamycin complex 1) protein kinase regulates growth in response to nutrients and growth factors. Nutrients promote its translocation to the lysosomal surface, where its Raptor subunit interacts with the Rag guanosine triphosphatase (GTPase)–Ragulator complex.

A transient protein megacomplex that controls degradation of cell ...

WebResearch & Scholarship Teaching Publications Bio Dr. Kacper Rogala is Assistant Professor at Stanford University School of Medicine with a joint appointment between the Department of Structural Biology and the Department of Chemical & Systems Biology. He is also a Leader in the Stanford Cancer Institute. WebMar 27, 2024 · The mammalian target of rapamycin complex 1 (mTORC1) drives many senescence phenotypes including mitochondrial biogenesis (Correia-Melo et al , 2016) and translation of SASP factors (Herranz et al , 2015; Laberge et al , 2015 ), and its inhibition by rapamycin can slow senescence onset (Carroll & Korolchuk, 2024 ). optima wellness

RRAGC Mutations Activate mTORC1 Signaling in Follicular …

WebJan 1, 2016 · Amino acids signal to mTORC1 through the Rag guanosine triphosphatases (GTPases). Several factors regulate the Rags, including GATOR1, aGTPase-activating protein; GATOR2, a positive regulator of unknown function; and Sestrin2, a GATOR2-interacting protein that inhibits mTORC1 signaling. WebNov 4, 2011 · The mTOR Complex 1 (mTORC1) protein kinase is a master growth regulator that is stimulated by amino acids. Amino acids activate the Rag guanosine triphosphatases (GTPases), which promote the translocation of mTORC1 to the lysosomal surface, the site of mTORC1 activation. WebJan 7, 2015 · In one model, mTORC1 indirectly senses amino acids within the lysosomal lumen that requires the Rag guanosine triphosphatases (GTPases), which are regulated by the pentameric Ragulator complex, the vacuolar H + –adenosine triphosphatase (v-ATPase), and the Gator complex ( 8, 9 ). optima webservice