WebSep 13, 2012 · In addition, rifampicin can reduce the plasma concentrations of drugs that are not metabolised (e.g. digoxin) by inducing drug transporters such as P-glycoprotein. Thus, the effects of rifampicin on drug metabolism and transport are broad and of established clinical significance. WebJun 9, 2024 · Here, we asked whether rifampicin (a model ligand of pregnane X receptor, PXR), at 30 μM, induces functional expression of ABCB1 in hPCISs over 24- and 48-h incubation (the time to allow complete induction to occur). Rifampicin significantly increased gene expression, protein levels, and efflux activity of ABCB1.
The role of intestinal P-glycoprotein in the interaction of digoxin …
WebIn addition, rifampicin can reduce the plasma concentrations of drugs that are not metabolised (e.g. digoxin) by inducing drug transporters such as P-glycoprotein. Thus, … WebMay 15, 2024 · The effects of rifampicin on the pharmacokinetics of digoxin were predicted in seven cases with varying dosing regimens. 6, 8, 9, 35, 36 The PBPK model of rifampicin including the P-gp inductive and inhibitory … sandals 3 deaths
Rifampin and Rifabutin Drug Interactions - JAMA
WebJun 20, 2024 · Rifapentine is a rifamycin antimycobacterial drug approved for tuberculosis (TB) treatment. For adults, 600 mg orally twice weekly is recommended during the intensive phase of TB treatment, followed by 600 mg once weekly during the continuation phase. WebAug 8, 2024 · This study provides whole-body PBPK models of rifampicin, itraconazole, clarithromycin, midazolam, alfentanil, and digoxin within the Open Systems Pharmacology (OSP) Suite. All models were built independently, coupled using reported interaction parameters, and mutually evaluated to verify their predictive performance by simulating … WebAug 4, 2014 · Induction or inhibition of intestinal P-glycoprotein appears to be a major mechanism underlying drug interactions that lead to reduced or elevated digoxin … sandals 3 americans dead